UHAMKA
Sistem Manajemen Kinerja Penelitian dan Pengabdian Masyarakat
Universitas Muhammadiyah Prof.Dr. Hamka

Luaran Penelitian Publikasi Jurnal

Detail Publikasi Jurnal

Personil Penulis
Nama Dosen: Dr. apt. Supandi M.Si.
NIDN: 0319067801
Program Studi: S1 Farmasi
Keanggotaan: anggota
Personil Penulis
Nama Dosen: Prof. Dr. Suswandari, M.Pd
NIDN: 0020116601
Program Studi: S1 Pendidikan Guru Sekolah Dasar
Keanggotaan: ketua
Personil Penulis
Nama Dosen: Yeni S.Farm., M.Si., Apt.
NIDN: 0308049102
Program Studi: S1 Farmasi
Keanggotaan: anggota
Data Publikasi Jurnal
Jenis Publikasi : International
Judul: Docking Studies and Molecular Dynamics Simulation of Ipomoea batatas L. Leaves Compounds as Lipoxygenase (LOX) Inhibitor
Nama Jurnal: Journal of Pharmacy and Bioallied Sciences
Abstrak: Inflammatory mediators produced by cyclooxygenase (COX) and
lipoxygenase (LOX) pathways are responsible for many human diseases, such
as cancer, arthritis, and neurological disorders. Flavonoid-containing plants,
such as Ipomoea batatas leaves, have shown potential anti-inflammatory
activity. Objectives: This study aimed to predict the actions of 10 compounds
in I. batatas leaves, which are YGM–0a [cyanidin 3–0–sophoroside–5–0–
glucosede], YGM–0f [cyanidin 3–O–(2–0–(6–0–(E)–p–coumaroyl–?–D–
glucopyranosyl)–?–D–glucopyranoside)–5–0–?–D–glucopyranoside],
YGM–1a [cyanidin 3–(6,6?–caffeylp–hydroxybenzoylsophoroside) –5–
glucoside], YGM–1b [cyanidin 3–(6,6?–dicaffeylsophor-oside)–5–glucoside],
YGM–2 [cyanidin 3–(6–caffeylsophoroside)–5–glucoside], YGM–3 [cyanidin
3–(6,6?–caffeyl-ferulylsophoroside)–5–glucoside], YGM–4b [peonidin 3–
(6,6?–dicaffeylsophoroside)–5– glucoside], YGM–5a [peonidin 3–(6,6?–
caffeylphydroxybenzo-ylsophoroside)–5–gluco-side], YGM–5b [cyanidin
3–6–caffeylsophoroside)–5–glucosede], and YGM–6 [peonidin 3–(6,6?–
caffeylferulylsophoroside)–5–glucoside] as LOX inhibitors, and also predict the
stability of ligand–LOX complex. Materials and Methods: The compounds were
screened through docking studies using PLANTS. Also, the molecular dynamics
simulation was conducted using GROMACS at 310 K. Results: The results
showed that the most significant binding affinity toward LOX was shown by
YGM–0a and YGM–0a, and the LOX complex in molecular dynamics simulation
showed stability for 20 ns. Conclusion: Based on Docking Studies
ISSN : -
Volume : 7
Nomor : 4932
Halaman : 836 - 839
URL : https://www.jpbsonline.org/
Tahun Kegiatan : 2020
Berkas : Download